Acute epigastric and low back pain during amiodarone infusion; is it the drug or the vehicle to blame?
Τίτλος | Acute epigastric and low back pain during amiodarone infusion; is it the drug or the vehicle to blame? |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Petrou, E., Iakovou I., Boutsikou M., Girasis C., Mavrogeni S., & Pavlides G. |
Journal | Heart Lung |
Volume | 43 |
Issue | 1 |
Pagination | 60-1 |
Date Published | 2014 Jan-Feb |
ISSN | 1527-3288 |
Λέξεις κλειδιά | Aged, 80 and over, Amiodarone, Anti-Arrhythmia Agents, Atrial Fibrillation, Female, Humans, Infusions, Intravenous, Low Back Pain, Male, Middle Aged, Polysorbates |
Abstract | Amiodarone is a Class III antiarrhythmic agent used for cardioversion and prevention of recurrences of atrial fibrillation. However, its use is limited due to its side-effects resulting from the drug's long-term administration. We have described acute epigastric pain following treatment with intravenous amiodarone for atrial fibrillation in a previous report. Hereby, we describe a second patient who suffered acute epigastric pain, as well as one who suffered acute low back pain. Intravenous amiodarone has been related to a series of minor and major adverse reactions, indicating other constituents of the intravenous solution as the possible cause, possibly polysorbate-80. A possible correlation between acute epigastric and low back pain after intravenous amiodarone loading is unproven; however it is of crucial importance for clinicians to be aware of this phenomenon, and especially since an acute epigastric pain is implicated in the differential diagnosis of cardiac ischemia. |
DOI | 10.1016/j.hrtlng.2013.09.005 |
Alternate Journal | Heart Lung |
PubMed ID | 24239300 |