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Aortic balloon valvuloplasty before transcatheter valve replacement in high-risk patients with aortic stenosis : Cardiac catheterization and echocardiographic hemodynamic study.

ΤίτλοςAortic balloon valvuloplasty before transcatheter valve replacement in high-risk patients with aortic stenosis : Cardiac catheterization and echocardiographic hemodynamic study.
Publication TypeJournal Article
Year of Publication2016
AuthorsKamperidis, V., Hadjimiltiades S., Mouratoglou S. A., Ziakas A., Sianos G., Sarafidou A., Ventoulis I., Kazinakis G., Giannakoulas G., Efthimiadis G. K., Parcharidis G., & Karvounis H.
JournalHerz
Volume41
Issue2
Pagination144-150
Date Published2016 Mar
ISSN1615-6692
Abstract

BACKGROUND: Balloon aortic valvuloplasty (BAV) has been revived as a bridge to transcatheter aortic valve replacement (TAVR). The aim of the current prospective study was to define a safe time period from BAV to TAVR and to determine hemodynamic variables that predict event-free survival after BAV.PATIENTS AND METHODS: The present prospective study included 68 consecutive patients with severe aortic stenosis who were treated initially with BAV from 2009 to 2012. Echocardiographic and invasive hemodynamic assessments were performed before BAV. The patients were followed up at regular intervals and events were defined as cardiac hospitalization or death.RESULTS: Invasive hemodynamic evaluation yielded more favorable results than echocardiographic assessment: aortic stenosis was less severe, cardiac output was higher, and pulmonary capillary wedge pressure (PCWP) was lower. Post-BAV event-free survival was 80.4 % at 30 days, 64.5 % at 6 months, 37 % at 1 year, 22.3 % at 2 years, and 9.3 % at 3 years. After excluding pre-discharge deaths (n = 7), the 30-day event-free survival rate was 90 %. Predictors of events after BAV were atrial fibrillation, cardiogenic shock, elevated euroSCORE (European System for Cardiac Operative Risk Evaluation), elevated PCWP, and elevated pulmonary artery systolic pressure. Invasively measured PCWP was the only independent predictor of events (hazard ratio, 1.07; 95 % confidence interval, 1.03-1.11; p = 0.001).CONCLUSION: A 30-day post-BAV period may be considered a bridge to TAVR. Furthermore, invasive assessment of PCWP before BAV is an independent hemodynamic predictor of events after BAV.

DOI10.1007/s00059-015-4353-9
Alternate JournalHerz
PubMed ID26383045

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