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Biomedical applications of synthetic, biodegradable polymers for the development of anti-infective strategies.

ΤίτλοςBiomedical applications of synthetic, biodegradable polymers for the development of anti-infective strategies.
Publication TypeJournal Article
Year of Publication2014
AuthorsBertesteanu, S., Chifiriuc M. Carmen, Grumezescu A. Mihai, Printza A. G., Marie-Paule T., Grumezescu V., Mihaela V., Lazar V., & Grigore R.
JournalCurr Med Chem
Volume21
Issue29
Pagination3383-90
Date Published2014
ISSN1875-533X
Abstract

The emergence of antibiotic resistance in microbial strains is representing one of the major threats to public health worldwide, due to the decreased or total cancelling of the available antibiotics effectiveness, correlated with the slow development of novel antibiotics. Due to their excellent biodegradability and biocompatibility, the synthetic polymers could find a lot of biomedical applications, such as the development of biomaterials with optimized properties and of drug delivery systems. This review is focusing on the applications of synthetic, biodegradable polymers for the improvement of antiinfective therapeutic and prophylactic agents (i.e., antimicrobial and anti-inflammatory agents and vaccines) activity, as well as for the design of biomaterials with increased biocompatibility and resistance to microbial colonization.

Alternate JournalCurr. Med. Chem.
PubMed ID24606501

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