Δημοσίευση

Clinical expression and morbidity of systemic lupus erythematosus during a post-diagnostic 5-year follow-up: a male:female comparison.

ΤίτλοςClinical expression and morbidity of systemic lupus erythematosus during a post-diagnostic 5-year follow-up: a male:female comparison.
Publication TypeJournal Article
Year of Publication2011
AuthorsStefanidou, S., Benos A., Galanopoulou V., Chatziyannis I., Kanakoudi F., Aslanidis S., Boura P., Sfetsios T., Settas L., Katsounaros M., Papadopoulou D., Giamalis P., Dombros N., Chatzistilianou M., & Garyfallos A.
JournalLupus
Volume20
Issue10
Pagination1090-4
Date Published2011 Oct
ISSN1477-0962
Λέξεις κλειδιάAdolescent, Adult, Aged, Aged, 80 and over, Child, Female, Follow-Up Studies, Gastrointestinal Diseases, Greece, Humans, Lung Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Lymphatic Diseases, Male, Middle Aged, Morbidity, Prospective Studies, Retrospective Studies, Sex Factors, Thrombosis, Young Adult
Abstract

The aim of this study was to analyse the prevalence of the most relevant clinical features of the diagnosis of systemic lupus erythematosus (SLE) in a sample of male patients with lupus as well as the incidence of the main causes of morbidity in a 5-year period after the diagnosis. A further aim of this study was to investigate the impact of gender on expression and morbidity of SLE. Data were collected from the medical records of 59 male and 535 female patients with SLE who were diagnosed at the hospitals in the region of Thessaloniki. Several differences in the expression and morbidity of the disease were found in relation to the gender of the patient. Male patients had a higher prevalence of thromboses, nephropathy, strokes, gastrointestinal tract symptoms and antiphospholipid syndrome when compared with female patients, but tended to present less often with arthralgia, hair loss, Raynaud's phenomenon and photosensitivity as the initial clinical manifestations. During the 5-year follow-up, positive associations have been found between male gender and the incidence of tendonitis, myositis, nephropathy and infections, particularly of the respiratory tract. In conclusion, this study has provided information regarding the features of clinical expression and morbidity in male patients, and has shown that gender is a possible factor that can influence the clinical expression of SLE.

DOI10.1177/0961203311403640
Alternate JournalLupus
PubMed ID21700658

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