Clostridium difficile infection: New insights into therapeutic options.
Τίτλος | Clostridium difficile infection: New insights into therapeutic options. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Kachrimanidou, M., Sarmourli T., Skoura L., Metallidis S., & Malisiovas N. |
Journal | Crit Rev Microbiol |
Pagination | 1-7 |
Date Published | 2015 May 8 |
ISSN | 1549-7828 |
Abstract | Clostridium difficile infection (CDI) is an important cause of mortality and morbidity in healthcare settings and represents a major social and economic burden. The major virulence determinants are large clostridial toxins, toxin A (TcdA) and toxin B (TcdB), encoded within the pathogenicity locus. Traditional therapies, such as metronidazole and vancomycin, frequently lead to a vicious circle of recurrences due to their action against normal human microbiome. New disease management strategies together with the development of novel therapeutic and containment approaches are needed in order to better control outbreaks and treat patients. This article provides an overview of currently available CDI treatment options and discusses the most promising therapies under development. |
DOI | 10.3109/1040841X.2015.1027171 |
Alternate Journal | Crit. Rev. Microbiol. |
PubMed ID | 25955884 |