Comparable effect of conventional ventilation versus early high-frequency oscillation on serum CC16 and IL-6 levels in preterm neonates.
Τίτλος | Comparable effect of conventional ventilation versus early high-frequency oscillation on serum CC16 and IL-6 levels in preterm neonates. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Sarafidis, K., Stathopoulou T., Agakidou E., Taparkou A., Soubasi V., Diamanti E., & Drossou V. |
Journal | J Perinatol |
Volume | 31 |
Issue | 2 |
Pagination | 104-11 |
Date Published | 2011 Feb |
ISSN | 1476-5543 |
Λέξεις κλειδιά | Biological Markers, Bronchoalveolar Lavage Fluid, High-Frequency Ventilation, Humans, Infant, Newborn, Infant, Premature, Interleukin-6, Respiratory Distress Syndrome, Newborn, Uteroglobin, Ventilator-Induced Lung Injury |
Abstract | OBJECTIVE: Clara cell 16 kD protein (CC16) and interleukin (IL)-6 have been used as peripheral blood biomarkers of alveolar leakage and inflammation, respectively. Thus, their measurement in the bloodstream could be used to assess ventilator-induced lung injury. The objective of this study was to evaluate the effect of optimized synchronized intermittent mandatory ventilation (SIMV) and high-frequency oscillatory ventilation (HFOV) on circulating CC16 and IL-6 levels when used as the initial ventilation modes in preterm neonates.STUDY DESIGN: Single center, prospective, randomized clinical study in preterm neonates (gestational age 30 weeks) requiring mechanical ventilation within the first 2 h of life. Serum CC16 and IL-6 were measured on establishment of the assigned ventilation mode after admission, at days 3 and 14 of life as well as at 36 weeks postmenstrual age. Demographic-perinatal data and clinical parameters were also recorded.RESULT: Of the 30 neonates studied, 24 (gestational age 27.1±1.7 weeks, birth weight 942±214 g) were finally analyzed, equally assigned into the SIMV and HFOV groups. Both groups had comparable demographic-perinatal characteristics and clinical parameters. Serum CC16 and IL-6 altered significantly over time (repeated-measures analysis of variance, both P<0.001). However, changes were not affected by the ventilation mode. Post hoc analysis showed a significant decrease in CC16 and IL-6 from birth up to 36 weeks postmenstrual age in both groups.CONCLUSION: In preterm neonates, SIMV and HFOV are associated with comparable circulating CC16 and IL-6 levels. These findings suggest a similar alveolar leakage and systemic inflammation with any of the ventilation modes evaluated when their usage is optimized. |
DOI | 10.1038/jp.2010.78 |
Alternate Journal | J Perinatol |
PubMed ID | 20671716 |