Δημοσίευση

Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.

ΤίτλοςComparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsChristoforidis, A., Printza N., Gkogka C., Siomou E., Challa A., Kazantzidou E., Kollios K., & Papachristou F.
JournalJ Bone Miner Metab
Volume29
Issue3
Pagination321-7
Date Published2011 May
ISSN1435-5604
Λέξεις κλειδιάAbsorptiometry, Photon, Adolescent, Case-Control Studies, Child, Female, Humans, Kidney Failure, Chronic, Male, Parathyroid Hormone, Radius, Renal Osteodystrophy, Tibia
Abstract

Our aim was to assess bone parameters in children with chronic kidney disease (CKD) with both dual-energy X-ray absorptiometry (DXA) and quantitative ultrasonography (QUS) and additionally with biochemical markers of bone turnover. Twenty children (12 boys and 8 girls) with CKD and a mean decimal age of 9.47 ± 4.44 years were included in the study where anthropometric parameters (height and weight), pubertal status, bone mineral density (BMD) at lumbar spine, speed of sound (SOS) measured by QUS at radius and at tibia, and biochemical markers of bone metabolism were measured. Six patients (30%) had tibial SOS Z score <-1, and 52.7% had radial SOS Z score <-1, whereas only 16.67% had BMD Z score <-1. Patients had significantly increased levels of serum intact parathormone (p < 0.001), serum bone alkaline phosphatase (BAP) (p < 0.001) and serum N-terminal-mid fragment (aminoacids 1-43) of osteocalcin (p < 0.001) compared to controls, whereas serum osteoprotegerin was significantly decreased in patients compared to controls (p = 0.001). SOS was significantly correlated to BAP (r = -0.586, p = 0.013 and r = -0.709, p = 0.001, respectively, for radius and tibia). In conclusion no association between DXA and QUS measurements was documented in our study, whereas QUS was better correlated to biochemical indices of ROD.

DOI10.1007/s00774-010-0220-1
Alternate JournalJ. Bone Miner. Metab.
PubMed ID20845051

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