Daptomycin use in a neonate: serum level monitoring and outcome.
| Τίτλος | Daptomycin use in a neonate: serum level monitoring and outcome. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Sarafidis, K., Iosifidis E., Gikas E., Tsivitanidou M., Drossou-Agakidou V., & Roilides E. |
| Journal | Am J Perinatol |
| Volume | 27 |
| Issue | 5 |
| Pagination | 421-4 |
| Date Published | 2010 May |
| ISSN | 1098-8785 |
| Λέξεις κλειδιά | Anti-Bacterial Agents, Daptomycin, Female, Gram-Positive Bacterial Infections, Humans, Infant, Newborn, Infant, Premature, Male, Treatment Outcome |
| Abstract | We present a case of successfully treated persistent bacteremia due to Gram-positive bacteria with daptomycin in a preterm neonate. Daptomycin was given at higher doses (6 mg/kg/dose) and shorter intervals (every 12 hours) than those recommended for adults with no adverse events. Peak and trough serum concentrations of daptomycin were 27.3 and 11.6 μg/mL [DOSAGE ERROR CORRECTED] at day 4 as well as 22.9 and 7.9 μg/mL [DOSAGE ERROR CORRECTED]at day 11 after initiation of treatment, respectively. |
| DOI | 10.1055/s-0029-1243370 |
| Alternate Journal | Am J Perinatol |
| PubMed ID | 20013573 |
