Decreased Axon Flare Reaction to Electrical Stimulation in Patients With Chronic Demyelinating Inflammatory Polyneuropathy.
Τίτλος | Decreased Axon Flare Reaction to Electrical Stimulation in Patients With Chronic Demyelinating Inflammatory Polyneuropathy. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Kokotis, P., Schmelz M., Papagianni A. E., Zambelis T., & Karandreas N. |
Journal | J Clin Neurophysiol |
Volume | 34 |
Issue | 2 |
Pagination | 101-106 |
Date Published | 2017 Mar |
ISSN | 1537-1603 |
Λέξεις κλειδιά | Adult, Aged, Axons, Electric Stimulation, Female, Humans, Male, Middle Aged, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Reflex, Skin |
Abstract | PURPOSE: In chronic inflammatory demyelinating polyradiculopathy (CIDP), the impairment of unmyelinated nerve fibers appears unexpected. The measurement of the electrically induced axon flare reflex is a clinical test to assess the peripheral C-nociceptor function. In this study, we compared the flare area in patients suffering from CIDP with healthy subjects.METHODS: We examined 18 patients fulfilling the criteria for CIDP (11 men, mean age 51.8 years, SD 15.1) and 18 age-matched adult healthy volunteers (control group) (11 men, mean age 51.9 years, SD 15.8). The flare responses were elicited by transcutaneous electrical stimulation and recorded by laser Doppler imaging.RESULTS: There was a significant reduction of electrically induced maximum flare area in the foot dorsum of patients with CIDP (t-value 2.08, P = 0.04) which proved to be length-dependent measured by a numerical index comparing the results with the forearm and thigh. The repeatedmeasures ANOVA revealed statistically significant smaller flare areas in all body regions for the CIDP group (P < 0.001).CONCLUSIONS: The axon flare reaction to electrical stimulation was decreased in patients with chronic demyelinating inflammatory polyneuropathy. The evaluation of the axon flare response can be proposed as a noninvasive objective functional test to detect an impaired C-fiber function in CIDP patients with the advantages of simplicity of the procedure, time economy, and objectivity. |
DOI | 10.1097/WNP.0000000000000294 |
Alternate Journal | J Clin Neurophysiol |
PubMed ID | 28257341 |