Effects of lipid lowering drugs on arterial stiffness. One more way to reduce cardiovascular risk?
Τίτλος | Effects of lipid lowering drugs on arterial stiffness. One more way to reduce cardiovascular risk? |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Reklou, A., Katsiki N., Karagiannis A., & Athyros V. |
Journal | Curr Vasc Pharmacol |
Date Published | 2019 Jan 20 |
ISSN | 1875-6212 |
Abstract | Arterial stiffness (AS) is considered an independent predictor of cardiovascular disease (CVD) events. Among lipid lowering drugs, statins have a beneficial effect on AS, independent of their hypolipidaemic effect. Based on 3 meta-analyses and other studies, this effect is compound- and dose-related. Potent statins at high doses are more effective than less powerful statins. Ezetimibe (± statin) also seems to decrease AS in patients with dyslipidaemia. Fibrates have no effect on AS. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have data that beneficially affect all AS risk factors, suggesting a beneficial effect on artery compliance. However, there is no direct measurement of their effect on AS indices. In patients with dyslipidaemia, prescribing high dose statins (± ezetimibe) will not only decrease low-density lipoprotein cholesterol levels but also improve AS (in addition to other effects). This effect on AS may contribute to the observed reduction in vascular events. |
DOI | 10.2174/1570161117666190121102323 |
Alternate Journal | Curr Vasc Pharmacol |
PubMed ID | 30663570 |