Efforts to counteract locally the effects of systemic immunosupression: a review on the use of imiquimod, a topical immunostimulator in organ transplant recipients.
Τίτλος | Efforts to counteract locally the effects of systemic immunosupression: a review on the use of imiquimod, a topical immunostimulator in organ transplant recipients. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Trakatelli, M., Katsanos G., Ulrich C., Kalabalikis D., Sotiriadis D., & Stockfleth E. |
Journal | Int J Immunopathol Pharmacol |
Volume | 23 |
Issue | 2 |
Pagination | 387-96 |
Date Published | 2010 Apr-Jun |
ISSN | 0394-6320 |
Λέξεις κλειδιά | Adjuvants, Immunologic, Aminoquinolines, Animals, Carcinoma, Basal Cell, Humans, Immune Tolerance, Keratosis, Actinic, Organ Transplantation, Sarcoma, Kaposi, Warts |
Abstract | The potent systemic immunosuppression therapy necessary to sustain a life-saving solid organ transplant is associated with an increased incidence of various infections including human papillomavirus infection and skin cancers in organ transplant recipients. Imiquimod, a topical agent that functions through local induction of a specific anti-viral or anti-tumor immune response, appears to be a promising therapeutic option that could potentially counteract in situ the effects of systemic immunosupression in this vulnerable group. Up-to-date studies using this local immune-response modifier in transplanted patients have yielded reassuring and encouraging results regarding its safety and efficacy in this population. However, in order to establish the use of imiquimod as a standard treatment option for organ transplant recipients, additional research and clinical trials are required. |
Alternate Journal | Int J Immunopathol Pharmacol |
PubMed ID | 20646334 |