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Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.

ΤίτλοςEnhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.
Publication TypeJournal Article
Year of Publication2015
AuthorsHohenforst-Schmidt, W., Zarogoulidis P., Stopek J., Kosmidis E., Vogl T., Linsmeier B., Tsakiridis K., Lampaki S., Lazaridis G., Mpakas A., Browning R., Papaiwannou A., Drevelegas A., Baka S., Karavasilis V., Mpoukovinas I., J Turner F., Zarogoulidis K., & Brachmann J.
JournalJ Cancer
Volume6
Issue3
Pagination218-26
Date Published2015
ISSN1837-9664
Abstract

Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

DOI10.7150/jca.10970
Alternate JournalJ Cancer
PubMed ID25663938
PubMed Central IDPMC4317756

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