Experimentation with inhaled bronchodilators and corticosteroids.
Τίτλος | Experimentation with inhaled bronchodilators and corticosteroids. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Zarogoulidis, P., Porpodis K., Kioumis I., Petridis D., Lampaki S., Spyratos D., Papaiwannou A., Organtzis J., Kontakiotis T., Manika K., Darwiche K., Freitag L., Tsiouda T., Papakosta D., & Zarogoulidis K. |
Journal | Int J Pharm |
Volume | 461 |
Issue | 1-2 |
Pagination | 411-8 |
Date Published | 2014 Jan 30 |
ISSN | 1873-3476 |
Λέξεις κλειδιά | Administration, Inhalation, Aerosols, Bronchodilator Agents, Equipment Design, Glucocorticoids, Nebulizers and Vaporizers, Ultrasonics |
Abstract | BACKGROUND: Inhaled bronchodilators and corticosteroids have been used for decades with different production systems.MATERIALS AND METHODS: The following jet-nebulizers: (a) Invacare, (b) Sunmist, (c) Maxineb and ultrasound nebulizers: (a) GIMA, (b) OMRON and (c) EASY NEB II were used as production systems. The jet-nebulizers were used with different residual cups and volume filling, while the ultrasound nebulizers with different volume fillings and face mask versus inlet.RESULTS: Inhalation and ultrasound process detect significant differences between the factors and interactions considered, but each technique follows a specific pattern of magnitude effect. Thus the inhaled mechanism ranks the factor effects in decreasing order: residual cup>drug>nebulizer>loading (2, 3, 4 ml) and also drug>residual cup>nebulizer (loading 8 ml). The ultrasound mechanism orders as follows: nebulizer>drug>loading. In fact, varying micro environmental conditions created during the performance of the devices in both processes alternate the magnitude of factor significance allowing for unique capacities.CONCLUSIONS: PULMICORT, MAXINEB, design cup J and loading 6 ml are the best options for the inhaled process. Optimal combinations are provided by FLIXOTIDE and cup B and also by MAXINEB and cup J. The incorporation of large residual cups suggests one out of six drugs, the SUNMIST nebulizer and design D as the best choices. Ultrasound performance informs for other optimal conditions: ZYLOREN, MAXINEB, 4 ml load and MAXINEB×loading 4 ml. |
DOI | 10.1016/j.ijpharm.2013.12.010 |
Alternate Journal | Int J Pharm |
PubMed ID | 24361267 |