Δημοσίευση

Genotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort.

ΤίτλοςGenotype and allele frequencies of heme oxygenase-1 promoter region in a Greek cohort.
Publication TypeJournal Article
Year of Publication2011
AuthorsKatana, E. P., Skoura L. G., Scouras Z. G., & Daniilidis M. A.
JournalChin Med J (Engl)
Volume124
Issue20
Pagination3408-11
Date Published2011 Oct
ISSN0366-6999
Λέξεις κλειδιάAdolescent, Adult, Female, Gene Frequency, Genotype, Greece, Heme Oxygenase-1, Humans, Male, Microsatellite Repeats, Middle Aged, Polymorphism, Genetic, Promoter Regions, Genetic, Young Adult
Abstract

BACKGROUND: Heme oxygenase-1 (HO-1) is an enzyme, which catabolizes heme into carbon monoxide, biliverdin and free iron. The induction of this enzyme is an important cytoprotective mechanism, which occurs as an adaptive and beneficial response to a wide variety of oxidant stimuli. HO-1 inducibility is mainly modulated by a (GT)(n) polymorphism in the promoter region, and has been shown that short (S) repeats are associated with greater up-regulation of HO-1, compared with long (L) repeats.METHODS: In the present study, 250 healthy Greek individuals have been screened in order to estimate the frequencies of (GT)(n) alleles in the HO-1 gene.RESULTS: Nineteen different alleles, ranging from 17 to 39 repeats, with (GT)(23) and (GT)(30) being the most common ones, were identified.CONCLUSION: The possible role of this polymorphism in disease states is discussed.

Alternate JournalChin. Med. J.
PubMed ID22088544

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