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Growth hormone replacement therapy in Costello syndrome.

ΤίτλοςGrowth hormone replacement therapy in Costello syndrome.
Publication TypeJournal Article
Year of Publication2014
AuthorsTriantafyllou, P., Christoforidis A., Vargiami E., & Zafeiriou D. I.
JournalGrowth Horm IGF Res
Volume24
Issue6
Pagination271-5
Date Published2014 Dec
ISSN1532-2238
Λέξεις κλειδιάCostello Syndrome, Hormone Replacement Therapy, Human Growth Hormone, Humans, Infant, Newborn, Male
Abstract

Costello syndrome (CS) is considered an overgrowth disorder given the macrosomia that is present at birth .However, shortly after birth the weight drops dramatically and the patients are usually referred for failure to thrive. Subsequently, affected patients develop the distinctive coarse facial appearance and are at risk for cardiac anomalies and solid tumor malignancies. Various endocrine disorders, although not very often, have been reported in patients with CS, including growth hormone deficiency, hypoglycemia, ACTH deficiency, cryptorchidism and hypothyroidism. We report a case of Costello syndrome with hypothyroidism, cryptorchidism and growth hormone deficiency and we evaluate the long-term safety and efficacy of growth hormone replacement therapy. The index patient is a paradigm of successful and safe treatment with growth hormone for almost 7 years. Since patients with CS are at increased risk for cardiac myopathy and tumor development they deserve close monitoring during treatment.

DOI10.1016/j.ghir.2014.10.001
Alternate JournalGrowth Horm. IGF Res.
PubMed ID25459872

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Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

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