Δημοσίευση

H NMR-based metabolomics reveals the effect of maternal habitual dietary patterns on human amniotic fluid profile.

ΤίτλοςH NMR-based metabolomics reveals the effect of maternal habitual dietary patterns on human amniotic fluid profile.
Publication TypeJournal Article
Year of Publication2018
AuthorsFotiou, M., Fotakis C., Tsakoumaki F., Athanasiadou E., Kyrkou C., Dimitropoulou A., Tsiaka T., Chatziioannou A. Chrysovala, Sarafidis K., Menexes G., Theodoridis G., Biliaderis C. G., Zoumpoulakis P., Athanasiadis A. P., & Michaelidou A-M.
JournalSci Rep
Volume8
Issue1
Pagination4076
Date Published2018 03 06
ISSN2045-2322
Λέξεις κλειδιάAmniotic Fluid, Biological Factors, Feeding Behavior, Female, Greece, Humans, Metabolome, Pregnancy
Abstract

Maternal diet may influence offspring's health, even within well-nourished populations. Amniotic fluid (AF) provides a rational compartment for studies on fetal metabolism. Evidence in animal models indicates that maternal diet affects AF metabolic profile; however, data from human studies are scarce. Therefore, we have explored whether AF content may be influenced by maternal diet, using a validated food-frequency questionnaire and implementing NMR-based metabolomics. Sixty-five AF specimens, from women undergoing second-trimester amniocentesis for prenatal diagnosis, were analysed. Complementary, maternal serum and urine samples were profiled. Hierarchical cluster analysis identified 2 dietary patterns, cluster 1 (C1, n = 33) and cluster 2 (C2, n = 32). C1 was characterized by significantly higher percentages of energy derived from refined cereals, yellow cheese, red meat, poultry, and "ready-to-eat" foods, while C2 by higher (P < 0.05) whole cereals, vegetables, fruits, legumes, and nuts. H NMR spectra allowed the identification of metabolites associated with these dietary patterns; glucose, alanine, tyrosine, valine, citrate, cis-acotinate, and formate were the key discriminatory metabolites elevated in C1 AF specimens. This is the first evidence to suggest that the composition of AF is influenced by maternal habitual dietary patterns. Our results highlight the need to broaden the knowledge on the importance of maternal nutrition during pregnancy.

DOI10.1038/s41598-018-22230-y
Alternate JournalSci Rep
PubMed ID29511239
PubMed Central IDPMC5840288

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