Δημοσίευση

Hepatitis B reactivation in a patient with rheumatoid arthritis with antibodies to hepatitis B surface antigen treated with rituximab.

ΤίτλοςHepatitis B reactivation in a patient with rheumatoid arthritis with antibodies to hepatitis B surface antigen treated with rituximab.
Publication TypeJournal Article
Year of Publication2013
AuthorsGigi, E., Georgiou T., Mougiou D., Boura P., & Raptopoulou-Gigi M.
JournalHippokratia
Volume17
Issue1
Pagination91-3
Date Published2013 Jan
ISSN1108-4189
Abstract

Hepatitis B virus (HBV) can still be found within the hepatocytes after its clearance and the control of viral replication depends on the immune response. However during immunosuppression, seroconversion of HBsAg has been described followed by disease reactivation. Hepatitis B virus reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents and in particular, by the use of rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and long-lasting immunosuppression. We describe a case of a 64-year old female patient with rheumatoid arthritis and resolved HBV infection, who experienced a severe hepatitis B reactivation after the administration of rituximab.

Alternate JournalHippokratia
PubMed ID23935355
PubMed Central IDPMC3738290

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