Δημοσίευση

High prevalence of Helicobacter pylori infection in Greek patients with myelodysplastic syndromes.

ΤίτλοςHigh prevalence of Helicobacter pylori infection in Greek patients with myelodysplastic syndromes.
Publication TypeJournal Article
Year of Publication2010
AuthorsDiamantidis, M. D., Ioannidou-Papagiannaki E., Kountouras J., Mandala E., Tsapournas G., Frida-Michailidou I., Klonizakis P., Zavos C., Haralambidou-Vranitsa S., Vlachaki E., Parapanisiou E., & Klonizakis I.
JournalActa Haematol
Volume124
Issue3
Pagination141-9
Date Published2010
ISSN1421-9662
Λέξεις κλειδιάAged, Antigens, CD, Case-Control Studies, Causality, Cohort Studies, Female, Greece, Helicobacter Infections, Helicobacter pylori, Humans, Leukemia, Myeloid, Acute, Lymphocytes, Male, Middle Aged, Myelodysplastic Syndromes
Abstract

BACKGROUND/AIMS/METHODS: To determine the frequency of Helicobacter pylori infection (Hp-I) in 73 patients with myelodysplastic syndromes (MDS) and 40 controls, serologic analyses of Hp and ¹³C-urease breath tests (INFAI) were performed. Gastric mucosal biopsy specimens were obtained to determine the presence of Hp-I using a rapid urease test, i.e. the Campylobacter-like organism (CLO) test, and cresyl violet staining. Peripheral blood (PB) flow cytometry for CD3, CD4, CD8, CD14, CD19 and CD34 was conducted in 35 patients and in controls.RESULTS: Hp-I was detected by: (a) serology in 75.34% of patients (p = 0.000), (b) INFAI in 57.69% of patients, (c) CLO in 60.71% of patients and (d) histological confirmation in 80.36% of patients (p = 0.001). No correlation between Hp-I and CD3, CD4, CD8, CD14, CD19 expression, leukemic transformation or death was observed. However, in 20 cases, significant variation in the PB lymphocytic proportion possibly attributable to Hp-I was ascertained, in contrast to the expected MDS ratio.CONCLUSION: Although there is no evidence for a causal relationship between Hp-I and MDS, the increased prevalence of Hp-I among the MDS patients is an interesting finding that deserves further investigation as it may indicate a common factor causing susceptibilities to both MDS and Hp-I or that Hp might influence the pathophysiology of MDS.

DOI10.1159/000319629
Alternate JournalActa Haematol.
PubMed ID20938168

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