Δημοσίευση

The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.

ΤίτλοςThe International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.
Publication TypeJournal Article
Year of Publication2017
AuthorsFountoulakis, K. N., Yatham L., Grunze H., Vieta E., Young A., Blier P., Kasper S., & Moeller H. Jurgen
JournalInt J Neuropsychopharmacol
Volume20
Issue2
Pagination121-179
Date Published2017 02 01
ISSN1469-5111
Λέξεις κλειδιάAdult, Algorithms, Antipsychotic Agents, Bipolar Disorder, Databases, Bibliographic, Guidelines as Topic, Humans, Meta-Analysis as Topic, Psychopharmacology
Abstract

Background: The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety.Material and Methods: The PRISMA method was used in the literature search with the combination of the words 'bipolar,' 'manic,' 'mania,' 'manic depression,' and 'manic depressive' with 'randomized,' and 'algorithms' with 'mania,' 'manic,' 'bipolar,' 'manic-depressive,' or 'manic depression.' Relevant web pages and review articles were also reviewed.Results: The current report is based on the analysis of 57 guideline papers and 531 published papers related to RCTs, reviews, posthoc, or meta-analysis papers to March 25, 2016. The specific treatment options for acute mania, mixed episodes, acute bipolar depression, maintenance phase, psychotic and mixed features, anxiety, and rapid cycling were evaluated with regards to efficacy. Existing treatment guidelines were also reviewed. Finally, Tables reflecting efficacy and recommendation levels were created that led to the development of a precise algorithm that still has to prove its feasibility in everyday clinical practice.Conclusions: A systematic literature search was conducted on the pharmacological treatment of bipolar disorder to identify all relevant random controlled trials pertaining to all aspects of bipolar disorder and graded the data according to a predetermined method to develop a precise treatment algorithm for management of various phases of bipolar disorder. It is important to note that the some of the recommendations in the treatment algorithm were based on the secondary outcome data from posthoc analyses.

DOI10.1093/ijnp/pyw100
Alternate JournalInt. J. Neuropsychopharmacol.
PubMed ID27816941
PubMed Central IDPMC5409012

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