Intravascular Ultrasonic Imaging of Coronary Arterial Remodeling in Heart Transplant Recipients.
Τίτλος | Intravascular Ultrasonic Imaging of Coronary Arterial Remodeling in Heart Transplant Recipients. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Goto, K., Iakovou I., Gkouziouta A., Maehara A., Mintz G. S., Karavolias G., Leontiadis V., Voudris V., Pavlides G., & Adamopoulos S. |
Journal | Am J Cardiol |
Volume | 116 |
Issue | 5 |
Pagination | 785-90 |
Date Published | 2015 Sep 1 |
ISSN | 1879-1913 |
Λέξεις κλειδιά | Adult, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Female, Follow-Up Studies, Heart Transplantation, Humans, Male, Reproducibility of Results, Retrospective Studies, Transplant Recipients, Ultrasonography, Interventional, Vascular Remodeling |
Abstract | The purpose of this study was to evaluate long-term changes of transplant coronary arteries, including vessel, plaque, and lumen areas. There are limited long-term data on vessel remodeling after heart transplantation. We analyzed serial intravascular ultrasound images of the left anterior descending coronary artery (LAD) in 54 heart transplantation recipients. Nine patients (16.7%) had a history of rejection. Proximal left anterior descending artery segments were matched among time points, a ≥20-mm long segment was analyzed every 1 mm, and results were normalized for analysis length and reported as mm(3)/mm. During follow-up, vessel area decreased (-0.48 ± 1.3 mm(3)/mm/year), and plaque area did not change (-0.01 ± 0.47 mm(3)/mm/year). As a result, lumen area decreased (-0.52 ± 1.34 mm(3)/mm/year). The change in mean lumen area was well correlated to the change in mean vessel area (r = 0.94, p <0.01) but not to the change in mean plaque area (r = -0.27, p = 0.05). In conclusion, lumen loss occurred during long-term follow-up of patients who underwent heart transplantation, primarily secondary to negative remodeling (decrease in vessel dimensions). |
DOI | 10.1016/j.amjcard.2015.05.051 |
Alternate Journal | Am. J. Cardiol. |
PubMed ID | 26100587 |