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Intravascular Ultrasonic Imaging of Coronary Arterial Remodeling in Heart Transplant Recipients.

ΤίτλοςIntravascular Ultrasonic Imaging of Coronary Arterial Remodeling in Heart Transplant Recipients.
Publication TypeJournal Article
Year of Publication2015
AuthorsGoto, K., Iakovou I., Gkouziouta A., Maehara A., Mintz G. S., Karavolias G., Leontiadis V., Voudris V., Pavlides G., & Adamopoulos S.
JournalAm J Cardiol
Volume116
Issue5
Pagination785-90
Date Published2015 Sep 1
ISSN1879-1913
Λέξεις κλειδιάAdult, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Female, Follow-Up Studies, Heart Transplantation, Humans, Male, Reproducibility of Results, Retrospective Studies, Transplant Recipients, Ultrasonography, Interventional, Vascular Remodeling
Abstract

The purpose of this study was to evaluate long-term changes of transplant coronary arteries, including vessel, plaque, and lumen areas. There are limited long-term data on vessel remodeling after heart transplantation. We analyzed serial intravascular ultrasound images of the left anterior descending coronary artery (LAD) in 54 heart transplantation recipients. Nine patients (16.7%) had a history of rejection. Proximal left anterior descending artery segments were matched among time points, a ≥20-mm long segment was analyzed every 1 mm, and results were normalized for analysis length and reported as mm(3)/mm. During follow-up, vessel area decreased (-0.48 ± 1.3 mm(3)/mm/year), and plaque area did not change (-0.01 ± 0.47 mm(3)/mm/year). As a result, lumen area decreased (-0.52 ± 1.34 mm(3)/mm/year). The change in mean lumen area was well correlated to the change in mean vessel area (r = 0.94, p <0.01) but not to the change in mean plaque area (r = -0.27, p = 0.05). In conclusion, lumen loss occurred during long-term follow-up of patients who underwent heart transplantation, primarily secondary to negative remodeling (decrease in vessel dimensions).

DOI10.1016/j.amjcard.2015.05.051
Alternate JournalAm. J. Cardiol.
PubMed ID26100587

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