Δημοσίευση

Left atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.

ΤίτλοςLeft atrial volume and N-terminal pro-B type natriuretic peptide are associated with elevated pulmonary artery pressure in patients with systemic sclerosis.
Publication TypeJournal Article
Year of Publication2010
AuthorsDimitroulas, T., Giannakoulas G., Papadopoulou K., Sfetsios T., Karvounis H., Dimitroula H., Parcharidou D., Koliakos G., Garyfallos A., Styliadis I., & Settas L.
JournalClin Rheumatol
Volume29
Issue9
Pagination957-64
Date Published2010 Sep
ISSN1434-9949
Λέξεις κλειδιάAged, Arginine, Biological Markers, Blood Pressure, Cross-Sectional Studies, Female, Follow-Up Studies, Heart Atria, Humans, Hypertension, Pulmonary, Male, Middle Aged, Multivariate Analysis, Natriuretic Peptide, Brain, Peptide Fragments, Predictive Value of Tests, Prospective Studies, Pulmonary Artery, Scleroderma, Systemic, Ventricular Dysfunction, Right
Abstract

Early detection of pulmonary hypertension (PH) in patients with systemic sclerosis (SSc) is essential as it leads to substantial morbidity and mortality irrespective of its etiology. The aim of our study was to determine whether noninvasive biochemical and/or echocardiographic indices can predict the presence of PH in these patients. We prospectively studied 66 patients (mean age of 57.7 +/- 12.1 years, 63 women) with SSc without clinical manifestations of heart failure. All patients underwent standard and tissue Doppler echocardiography. Plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) and asymmetric dimethylarginine (ADMA) levels were also measured. In 24 (36%) patients, the diagnosis of PH was established by echocardiography (systolic pulmonary artery pressure value > or =40 mmHg). Left atrial (LA) volume, NT-proBNP, ADMA, ratio of early transmitral filling velocity to early diastolic velocity of the mitral annulus (mitral E/E (m)), and right ventricular myocardial performance index (MPI) were univariate predictors of PH. In multivariate analysis, NT-proBNP, LA volume, and right ventricular MPI were independent predictors of PH in SSc patients. LA volume and NT-proBNP may be useful noninvasive markers for the prediction of elevated pulmonary artery pressure in patients with SSc. These parameters should be considered when assessing this population for risk stratification and for identification of patients demanding further investigation and institution of specific therapy for the disease at the time when it is most likely to be effective.

DOI10.1007/s10067-010-1494-3
Alternate JournalClin. Rheumatol.
PubMed ID20526641

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