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Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review.

ΤίτλοςLife-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review.
Publication TypeJournal Article
Year of Publication2010
AuthorsKefala-Agoropoulou, K., Protonotariou E., Vitti D., Sarafidou S., Anastasiou A., Kollios K., & Roilides E.
JournalEur J Pediatr
Volume169
Issue1
Pagination47-53
Date Published2010 Jan
ISSN1432-1076
Λέξεις κλειδιάBacterial Proteins, Bacterial Toxins, Child, DNA, Bacterial, Exotoxins, Female, Follow-Up Studies, Humans, Leukocidins, Magnetic Resonance Imaging, Methicillin Resistance, Methicillin-Resistant Staphylococcus aureus, Polymerase Chain Reaction, Staphylococcal Infections
Abstract

We report an unusual case of serious, multifocal, invasive infection due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in a 10-year-old girl with favorable outcome. The child manifested femoral osteomyelitis, pyomyositis, deep femoral vein thrombosis, pneumonia, encephalopathy, and disturbances of almost all organs. She remained in a critical condition for a week. Fever persisted for 6 weeks and acute phase reactants remained increased for 6 months, necessitating a 7-month antistaphylococcal therapy with a glycopeptide and clindamycin. This led to resolution of infection-associated problems during the subsequent 36 months of follow-up. CA-MRSA strain isolated from the patient harbored both staphylococcal chromosomal cassette type IV (SCCmec type IV) and Panton-Valentine leukocidin genes. A literature review of serious CA-MRSA infections indicated that only a small minority of published cases had favorable outcome.

DOI10.1007/s00431-009-0977-1
Alternate JournalEur. J. Pediatr.
PubMed ID19343363

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