Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era.
Τίτλος | Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Karras, S. N., Anagnostis P., Bili E., Naughton D., Petroczi A., Papadopoulou F., & Goulis D. G. |
Journal | Osteoporos Int |
Volume | 25 |
Issue | 3 |
Pagination | 795-805 |
Date Published | 2014 Mar |
ISSN | 1433-2965 |
Λέξεις κλειδιά | Bone Density, Bone Development, Calcium, Dietary Supplements, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Complications, Prenatal Care, Prenatal Exposure Delayed Effects, Prenatal Nutritional Physiological Phenomena, Rickets, Vitamin D, Vitamin D Deficiency |
Abstract | Data from animal and human studies implicate maternal vitamin D deficiency during pregnancy as a significant risk factor for several adverse outcomes affecting maternal, fetal, and child health. The possible associations of maternal vitamin D status and offspring bone development comprise a significant public health issue. Evidence from randomized trials regarding maternal vitamin D supplementation for optimization of offspring bone mass is lacking. In the same field, data from observational studies suggest that vitamin D supplementation is not indicated. Conversely, supplementation studies provided evidence that vitamin D has beneficial effects on neonatal calcium homeostasis. Nevertheless, a series of issues, such as technical difficulties of current vitamin D assays and functional interplay among vitamin D analytes, prohibit arrival at safe conclusions. Future studies would benefit from adoption of a gold standard assay, which would unravel the functions of vitamin D analytes. This narrative review summarizes and discusses data from both observational and supplementation studies regarding maternal vitamin D status during pregnancy and offspring bone development. |
DOI | 10.1007/s00198-013-2468-5 |
Alternate Journal | Osteoporos Int |
PubMed ID | 23907574 |