Δημοσίευση

Pro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer.

ΤίτλοςPro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer.
Publication TypeJournal Article
Year of Publication2009
AuthorsLafaras, C., Mandala E., Saratzis A., Platogiannis D., Barbetakis N., Papoti S., Christopoulou M., Ilonidis G., & Bischiniotis T.
JournalOnkologie
Volume32
Issue7
Pagination389-92
Date Published2009 Jul
ISSN1423-0240
Λέξεις κλειδιάAged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Female, Heart Neoplasms, Humans, Lung Neoplasms, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Reproducibility of Results, Sensitivity and Specificity, Tumor Markers, Biological
Abstract

BACKGROUND: B-type natriuretic peptide (BNP) and N-terminal-pro-BNP (NT-pro-BNP) are important diagnostic tools for patients with suspected cardiac disorders. The aim of this study was to evaluate the predictive value of plasma NT-pro-BNP in identifying cardiac metastases in patients with non-small cell lung cancer (NSCLC) and dyspnoea.PATIENTS AND METHODS: A total of 120 patients, median age 62 years (range 46-83), with NSCLC and dyspnoea were studied. Patients with heart failure or documented coronary artery disease were excluded. Echocardiographic imaging was used to detect cardiac metastases and estimate global left ventricular function. Ejection fraction and E/A ratio from transmitral inflow pattern were calculated. Plasma NT-pro-BNP was also measured. 72 patients (72/120, 60%) with cardiac metastases were identified.RESULTS: NT-pro-BNP was significantly higher in patients with metastases (1347.5 +/- 1004.30 pg/ml vs. 159.02 +/- 93.29 pg/ml; p = 0.001). No differences between groups, regarding s-creatinine (p = 0.45), haemoglobin (p = 0.71), left ventricular hypertrophy (p = 0.91), and diastolic dysfunction (p = 0.79), were observed.CONCLUSION: Plasma NT-pro-BNP is remarkably elevated in patients with NSCLC and myocardial/pericardial infiltrations and may be used as a sensitive marker for detecting cardiac metastases in these patients.

DOI10.1159/000218368
Alternate JournalOnkologie
PubMed ID19556815

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