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Receptor activator of nuclear factor κB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease.

ΤίτλοςReceptor activator of nuclear factor κB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease.
Publication TypeJournal Article
Year of Publication2016
AuthorsSpartalis, M., & Papagianni A.
JournalWorld J Nephrol
Volume5
Issue1
Pagination1-5
Date Published2016 Jan 06
ISSN2220-6124
Abstract

Vascular calcifications are commonly observed in patients with chronic kidney disease (CKD) and contribute to the excessive cardiovascular morbidity and mortality rates observed in these patients populations. Although the pathogenetic mechanisms are not yet fully elucidated, recent evidence suggests a link between bone metabolism and the development and progression of vascular calcifications. Moreover, accumulating data indicate that receptor activator of nuclear factor κB ligand/osteoprotegerin axis which plays essential roles in the regulation of bone metabolism is also involved in extra-osseous bone formation. Further studies are required to establish the prognostic significance of the above biomarkers as predictors of the presence and severity of vascular calcifications in CKD patients and of cardiovascular morbidity and mortality. Moreover, randomized clinical trials are needed to clarify whether inhibition of osteoclast activity will protect from vascular calcifications.

DOI10.5527/wjn.v5.i1.1
Alternate JournalWorld J Nephrol
PubMed ID26788459
PubMed Central IDPMC4707161

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