The sirtuin1 gene associates with left ventricular myocardial hypertrophy and remodeling in two chronic kidney disease cohorts: a longitudinal study.
Τίτλος | The sirtuin1 gene associates with left ventricular myocardial hypertrophy and remodeling in two chronic kidney disease cohorts: a longitudinal study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Spoto, B., Ntounousi E., Testa A., Liakopoulos V., D'Arrigo G., Tripepi G., Parlongo R. M., Sanguedolce M. C., Mallamaci F., & Zoccali C. |
Journal | J Hypertens |
Volume | 36 |
Issue | 8 |
Pagination | 1705-1711 |
Date Published | 2018 08 |
ISSN | 1473-5598 |
Λέξεις κλειδιά | Adult, Aged, Alleles, Cross-Sectional Studies, Female, Humans, Hypertrophy, Left Ventricular, Kidney Failure, Chronic, Longitudinal Studies, Male, Middle Aged, Polymorphism, Single Nucleotide, Renal Insufficiency, Chronic, Sirtuin 1, Ventricular Remodeling |
Abstract | BACKGROUND: Oxidative stress and inflammation are major drivers of myocardial hypertrophy in chronic kidney disease (CKD). The silent information regulator gene 1 (Sirt1) is a fundamental mediator of the response to oxidative stress and inflammation and promotes myocardial growth under stress conditions; therefore, it may contribute to myocardial hypertrophy and concentric remodeling of the left ventricle (LV) in CKD.METHODS: We investigated the cross-sectional and longitudinal relationship between three candidate polymorphisms in the Sirt1 gene and LV parameters in two cohorts of CKD patients including 235 stage G5D patients and 179 stages G1-5 patients, respectively.RESULTS: In both cohorts, the C allele of the Sirt1 rs7069102 polymorphism associated with the posterior wall thickness in separate and combined analyses (beta = 0.15, P = 2 × 10) but was unrelated with the LV volume and the LV mass index indicating a peculiar association of this allele with LV concentric remodeling. Accordingly, the same allele was linked with the LV mass-to-volume ratio in separate and combined (beta = 0.14, P = 2 × 10) analyses in the same cohorts. Furthermore, in longitudinal analyses patients harboring the C allele showed a more pronounced increase in LV mass-to-volume ratio over time than patients without such an allele (regression coefficient = 0.14, 95% confidence interval: 0.05-0.23; P = 3 × 10 in the combined analysis).CONCLUSION: The rs7069102 polymorphism in the Sirt1 gene is associated with LV concentric remodeling in two independent cohorts of stages G5D and G1-5 CKD patients. These results offer a genetic basis to the hypothesis that the Sirt1 gene plays a causal role in myocardial hypertrophy and LV concentric remodeling in these patients. |
DOI | 10.1097/HJH.0000000000001746 |
Alternate Journal | J Hypertens |
PubMed ID | 29702498 |