Thyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case-control study.
Τίτλος | Thyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case-control study. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Toulis, K. A., Goulis D. G., Tsolakidou K., Hilidis I., Fragkos M., Polyzos S. A., Gerofotis A., Kita M., Bili H., Vavilis D., Daniilidis M., Tarlatzis B. C., & Papadimas I. |
Journal | Gynecol Endocrinol |
Volume | 29 |
Issue | 8 |
Pagination | 793-6 |
Date Published | 2013 Aug |
ISSN | 1473-0766 |
Λέξεις κλειδιά | Abortion, Spontaneous, Adult, Autoantibodies, Case-Control Studies, Female, Gestational Age, Hashimoto Disease, Humans, Middle Aged, Pregnancy, Pregnancy Outcome, Receptors, Thyrotropin, Risk Factors, Seroepidemiologic Studies |
Abstract | We have previously hypothesized that early miscarriage in women with Hashimoto thyroiditis might be the result of a cross-reactivity process, in which blocking autoantibodies against thyrotropin receptor (TSHr-Ab) antagonize hCG action on its receptor on the corpus luteum. To test this hypothesis from the clinical perspective, we investigated the presence of TSHr-Ab in Hashimoto thyroiditis patients with apparently unexplained, first-trimester recurrent miscarriages compared to that in Hashimoto thyroiditis patients with documented normal fertility. A total of 86 subjects (43 cases and 43 age-matched controls) were finally included in a case-control study. No difference in the prevalence of TSHr-Ab positivity was detected between cases and controls (Fisher's exact test, p value = 1.00). In patients with recurrent miscarriages, TSHr-Ab concentrations did not predict the number of miscarriages (univariate linear regression, p value = 0.08). These results were robust in sensitivity analyses, including only cases with full investigation or those with three or more miscarriages. We conclude that no role could be advocated for TSHr-Ab in the aetiology of recurrent miscarriages in women with Hashimoto thyroiditis. |
DOI | 10.3109/09513590.2013.801449 |
Alternate Journal | Gynecol. Endocrinol. |
PubMed ID | 23741968 |