Δημοσίευση

Thyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case-control study.

ΤίτλοςThyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case-control study.
Publication TypeJournal Article
Year of Publication2013
AuthorsToulis, K. A., Goulis D. G., Tsolakidou K., Hilidis I., Fragkos M., Polyzos S. A., Gerofotis A., Kita M., Bili H., Vavilis D., Daniilidis M., Tarlatzis B. C., & Papadimas I.
JournalGynecol Endocrinol
Volume29
Issue8
Pagination793-6
Date Published2013 Aug
ISSN1473-0766
Λέξεις κλειδιάAbortion, Spontaneous, Adult, Autoantibodies, Case-Control Studies, Female, Gestational Age, Hashimoto Disease, Humans, Middle Aged, Pregnancy, Pregnancy Outcome, Receptors, Thyrotropin, Risk Factors, Seroepidemiologic Studies
Abstract

We have previously hypothesized that early miscarriage in women with Hashimoto thyroiditis might be the result of a cross-reactivity process, in which blocking autoantibodies against thyrotropin receptor (TSHr-Ab) antagonize hCG action on its receptor on the corpus luteum. To test this hypothesis from the clinical perspective, we investigated the presence of TSHr-Ab in Hashimoto thyroiditis patients with apparently unexplained, first-trimester recurrent miscarriages compared to that in Hashimoto thyroiditis patients with documented normal fertility. A total of 86 subjects (43 cases and 43 age-matched controls) were finally included in a case-control study. No difference in the prevalence of TSHr-Ab positivity was detected between cases and controls (Fisher's exact test, p value = 1.00). In patients with recurrent miscarriages, TSHr-Ab concentrations did not predict the number of miscarriages (univariate linear regression, p value = 0.08). These results were robust in sensitivity analyses, including only cases with full investigation or those with three or more miscarriages. We conclude that no role could be advocated for TSHr-Ab in the aetiology of recurrent miscarriages in women with Hashimoto thyroiditis.

DOI10.3109/09513590.2013.801449
Alternate JournalGynecol. Endocrinol.
PubMed ID23741968

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