Treatment of male genital lichen sclerosus with clobetasol propionate and maintenance with either methylprednisolone aceponate or tacrolimus: a retrospective study.
Τίτλος | Treatment of male genital lichen sclerosus with clobetasol propionate and maintenance with either methylprednisolone aceponate or tacrolimus: a retrospective study. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Kyriakou, A., Patsialas C., Patsatsi A., & Sotiriadis D. |
Journal | J Dermatolog Treat |
Volume | 24 |
Issue | 6 |
Pagination | 431-4 |
Date Published | 2013 Dec |
ISSN | 1471-1753 |
Λέξεις κλειδιά | Adult, Clobetasol, Genital Diseases, Male, Humans, Lichen Sclerosus et Atrophicus, Maintenance Chemotherapy, Male, Methylprednisolone, Pruritus, Quality of Life, Retrospective Studies, Secondary Prevention, Skin Cream, Tacrolimus |
Abstract | OBJECTIVE: To assess the efficacy of clobetasol propionate 0.05% cream in male patients suffering from genital lichen sclerosus (GLS), as well as the efficacy of methylprednisolone aceponate 0.1% cream and tacrolimus 0.1% ointment as maintenance therapy.METHODS: The study was conducted retrospectively. At baseline, male patients with GLS (n = 41) were treated with clobetasol propionate 0.05% cream applied twice daily for 8 weeks. Visual Analog Scale (VAS) score for pruritus, Investigator's Global Assessment (IGA) score and Dermatology Life Quality Index (DLQI) were recorded at baseline, week 8 and week 20. At week 8, patients responsive to treatment (n = 37) were further treated with methylprednisolone aceponate 0.1% cream twice weekly (n = 17) or tacrolimus 0.1% ointment once daily (n = 20), as maintenance therapy until week 20.RESULTS: VAS, IGA and DLQI median scores were significantly decreased from baseline to week 8 (p < 0.001). At week 20, patients treated with methylprednisolone aceponate 0.1% cream presented no significant difference in median IGA score (p = 0.865), median DLQI score (p = 0.853) or median VAS score (p = 0.474) compared with patients treated with tacrolimus 0.1% ointment.CONCLUSIONS: Clobetasol propionate 0.05% cream is effective as first-line treatment in male GLS. The data suggest that there is no difference between methylprednisolone aceponate 0.1% cream and tacrolimus 0.1% ointment in preventing the relapses. |
DOI | 10.3109/09546634.2013.782385 |
Alternate Journal | J Dermatolog Treat |
PubMed ID | 23472631 |