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Anti-dopamine D2 receptor antibodies in chronic tic disorders.

ΤίτλοςAnti-dopamine D2 receptor antibodies in chronic tic disorders.
Publication TypeJournal Article
Year of Publication2020
AuthorsAddabbo, F., Baglioni V., Schrag A., Schwarz M. J., Dietrich A., Hoekstra P. J., Martino D., & Buttiglione M.
Corporate AuthorsEMTICS Collaborative Group
JournalDev Med Child Neurol
Volume62
Issue10
Pagination1205-1212
Date Published2020 10
ISSN1469-8749
Λέξεις κλειδιάAdolescent, Autoantibodies, Child, Child, Preschool, Female, Humans, Male, Receptors, Dopamine D2, Tic Disorders
Abstract

AIM: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs).
METHOD: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4-16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar's test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders.
RESULTS: At exacerbation, 11 (8%) participants became anti-D2R-positive ('early peri-exacerbation seroconverters'), and nine (6.6%) became anti-D2R-positive at post-exacerbation ('late peri-exacerbation seroconverters'). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar's odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs.
INTERPRETATION: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.

DOI10.1111/dmcn.14613
Alternate JournalDev Med Child Neurol
PubMed ID32644201
Grant List278367 / / FP7 Health / International

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