Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece.
| Τίτλος | Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Mastrogianni, O., Gbandi E., Orphanidis A., Raikos N., Goutziomitrou E., Kolibianakis E. M., Tarlatzis B. C., & Goulas A. |
| Journal | Drug Metab Pharmacokinet |
| Volume | 29 |
| Issue | 2 |
| Pagination | 215-8 |
| Date Published | 2014 |
| ISSN | 1880-0920 |
| Λέξεις κλειδιά | Adult, Anesthetics, Intravenous, Biotransformation, Cytochrome P-450 CYP2B6, Female, Gas Chromatography-Mass Spectrometry, Genotype, Greece, Humans, Injections, Intravenous, Oocyte Retrieval, Phenotype, Polymorphism, Single Nucleotide, Propofol, Sex Factors |
| Abstract | Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an extensively metabolized intravenous anesthetic. In this study we examined the effect of the apparently functional CYP2B6 c.516G>T polymorphism on the distribution of propofol concentrations, quantified by GC/MS analysis following a single bolus dose, in the blood of 44 Greek women undergoing oocyte retrieval. Univariate analysis using age, height, weight and smoking status as covariates, as well as the Mann-Whitney non-parametric test, revealed a strong trend of association of the T allele with high propofol concentrations determined in whole blood, shortly after a single bolus dose. Propofol concentrations which were higher than one standard deviation of the mean were almost invariably associated with carriage of the T allele. |
| Alternate Journal | Drug Metab. Pharmacokinet. |
| PubMed ID | 24153159 |
