Δημοσίευση

The Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease.

ΤίτλοςThe Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease.
Publication TypeJournal Article
Year of Publication2020
AuthorsRoumeliotis, S., Roumeliotis A., Stamou A., Leivaditis K., Kantartzi K., Panagoutsos S., & Liakopoulos V.
JournalInt J Mol Sci
Volume21
Issue17
Date Published2020 Aug 21
ISSN1422-0067
Abstract

We aimed to investigate the possible association of the inactive, dephosphorylated, uncarboxylated matrix Gla protein (dp-ucMGP) with oxidized low-density lipoprotein (ox-LDL) and all-cause/cardiovascular (CV) mortality and renal function in diabetic chronic kidney disease (CKD). Ox-LDL and dp-ucMGP were determined in 66 diabetic CKD patients. All patients were prospectively followed for seven years, or until the occurrence of death, or a composite renal outcome of 30% estimated glomerular filtration rate (eGFR) reduction or progression to end-stage renal disease (ESRD) requiring dialysis occurred. Secondary outcomes were the occurrence of CV events. Kaplan-Meier curves showed that patients with plasma dp-ucMGP levels above the median (≥656 pM) had a significantly higher risk for all study endpoints. After adjustment for several well-known cofounders, multivariate Cox analysis showed that high plasma dp-ucMGP levels were associated with all-cause mortality (Hazard ratio-HR = 2.63, 95% Confidence Interval-CI = 1.17-5.94, = 0.02), CV mortality (HR = 2.82, 95% CI = 1.07-7.49, = 0.037) and progression of CKD (HR = 4.02, 95% CI = 1.20-13.46, = 0.024). Circulating dp-ucMGP is associated with mortality and decreased renal function in diabetic CKD.

DOI10.3390/ijms21176035
Alternate JournalInt J Mol Sci
PubMed ID32839405
PubMed Central IDPMC7504709

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