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Association of non-invasive hemodynamics with arterial stiffness in rheumatoid arthritis.

ΤίτλοςAssociation of non-invasive hemodynamics with arterial stiffness in rheumatoid arthritis.
Publication TypeJournal Article
Year of Publication2018
AuthorsAnyfanti, P., Triantafyllou A., Gkaliagkousi E., Koletsos N., Aslanidis S., & Douma S.
JournalScand Cardiovasc J
Volume52
Issue4
Pagination171-176
Date Published2018 08
ISSN1651-2006
Λέξεις κλειδιάAdrenal Cortex Hormones, Aged, Arthritis, Rheumatoid, Cardiography, Impedance, Cardiovascular Diseases, Case-Control Studies, Chi-Square Distribution, Female, Hemodynamics, Humans, Inflammation Mediators, Linear Models, Male, Middle Aged, Multivariate Analysis, Myocardial Contraction, Pulse Wave Analysis, Risk Factors, Stroke Volume, Vascular Stiffness, Ventricular Function, Left
Abstract

OBJECTIVES: Arterial stiffness has emerged as a surrogate marker of cardiovascular disease. We investigated the role of myocardial performance and hemodynamic parameters in arterial stiffness in patients with rheumatoid arthritis (RA), which is accompanied by excess cardiovascular risk.DESIGN: Arterial stiffness was evaluated with pulse wave velocity (PWV) in RA patients and controls. Cardiac and hemodynamic characterization was based on impedance cardiography. Cardiovascular risk factors, inflammatory markers and disease-related parameters were assessed.RESULTS: PWV (8.2 ± 2.1 vs 7.4 ± 1.4 m/s, p = .016) was higher among RA patients (n = 104) compared to controls (n = 52). In the RA group, PWV correlated with markers of cardiac contractibility (acceleration and velocity index), myocardial blood flow (cardiac output and stroke volume), preload (thoracic fluid content) and afterload (systemic vascular resistance) (p < .05 for all). PWV tended to increase with decreasing oxygen delivery to the myocardium (r = 0.055), as well as with shortening of the ejection duration of the left ventricle (p = .058). However, these associations no longer remained significant after adjustment for classical cardiovascular risk factors, inflammation and corticosteroid use, which were independently associated with PWV.CONCLUSIONS: Among patients with RA, arterial stiffness appears as the composite of cardiovascular risk factors and inflammation, while corticosteroid use emerges as an additional adverse factor.

DOI10.1080/14017431.2018.1453943
Alternate JournalScand Cardiovasc J
PubMed ID29560750

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