An association study between catalase -262C>T gene polymorphism, sodium-lithium countertransport activity, insulin resistance, blood lipid parameters and their response to atorvastatin, in Greek dyslipidaemic patients and normolipidaemic controls.
Τίτλος | An association study between catalase -262C>T gene polymorphism, sodium-lithium countertransport activity, insulin resistance, blood lipid parameters and their response to atorvastatin, in Greek dyslipidaemic patients and normolipidaemic controls. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Kosmidou, M., Hatzitolios A. I., Molyva D., Raikos N., Savopoulos C., Daferera N., Kokkas V., & Goulas A. |
Journal | Free Radic Res |
Volume | 43 |
Issue | 4 |
Pagination | 385-9 |
Date Published | 2009 Apr |
ISSN | 1029-2470 |
Λέξεις κλειδιά | Adult, Alleles, Antiporters, Case-Control Studies, Catalase, Dyslipidemias, Erythrocytes, Female, Greece, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Insulin Resistance, Linear Models, Lipids, Male, Middle Aged, Polymorphism, Single Nucleotide, Pyrroles, Retrospective Studies |
Abstract | This study attempted to examine the effect of a functional catalase gene polymorphism, CAT -262C>T, on sodium-lithium countertransport (Na-Li CT) activity, insulin resistance determined as the homeostasis model assessment index (HOMA-IR), blood lipid parameters (cholesterol, triglycerides, low density lipoprotein cholesterol, high density lipoprotein cholesterol, apolipoprotein B, apolipoprotein A-I) and their response to atorvastatin, in previously characterized Greek dyslipidaemic patients and normolipidaemic controls. Putative associations were examined by running univariate analyses with a general linear model, using age, sex, smoking and hypertension as covariates. While no statistically significant associations were detected between the CAT -262C>T polymorphism and either baseline values or their modulation by atorvastatin in the patient group, HOMA-IR values were significantly (p=0.028) lower among CAT -262CC controls compared to their T allele carrier counterparts. A trend towards higher plasma triglyceride values among CAT -262CC genotypes was also detected, in both dyslipidaemic patients and normolipidaemic controls. |
DOI | 10.1080/10715760902783293 |
Alternate Journal | Free Radic. Res. |
PubMed ID | 19274593 |