Association of the Tau haplotype with Parkinson's disease in the Greek population.
Τίτλος | Association of the Tau haplotype with Parkinson's disease in the Greek population. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Fidani, L., Kalinderi K., Bostantjopoulou S., Clarimón J., Goulas A., Katsarou Z., Hardy J., & Kotsis A. |
Journal | Mov Disord |
Volume | 21 |
Issue | 7 |
Pagination | 1036-9 |
Date Published | 2006 Jul |
ISSN | 0885-3185 |
Λέξεις κλειδιά | Aged, Female, Gene Frequency, Genetics, Population, Genotype, Haplotypes, Humans, Male, Middle Aged, Parkinson Disease, Polymorphism, Genetic, Reference Values, tau Proteins |
Abstract | We compared the distribution of the Tau H1 haplotype and related subhaplotypes in a group of clinically diagnosed Parkinson's disease patients (n = 133) and in control individuals (n = 113) from northern Greece. We were able to detect a statistically significant overrepresentation of the H1H1 genotype in our patient group (OR for H1H1 vs. H1H2 and H2H2: 1.73; 95% CI: 1.03-2.90; P = 0.037). The H1 subhaplotype significantly associated with the disease in our population was different from the one previously reported for a Norwegian population, suggesting that the nature of the association of Tau with Parkinson's disease is influenced by ethnic variation. |
DOI | 10.1002/mds.20864 |
Alternate Journal | Mov Disord |
PubMed ID | 16552760 |
Grant List | G-0907 / / Parkinson's UK / United Kingdom G0701075 / / Medical Research Council / United Kingdom |