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Causes and incidence of renal replacement therapy application in orthotopic liver transplantation patients: our experience.

ΤίτλοςCauses and incidence of renal replacement therapy application in orthotopic liver transplantation patients: our experience.
Publication TypeJournal Article
Year of Publication2014
AuthorsPapadopoulos, S., Karapanagiotou A., Kydona C., Dimitriadis C., Theodoridou T., Piperidou M., Imvrios G., Fouzas I., & Gritsi-Gerogianni N.
JournalTransplant Proc
Volume46
Issue9
Pagination3228-31
Date Published2014 Nov
ISSN1873-2623
Λέξεις κλειδιάAcute Kidney Injury, Aged, End Stage Liver Disease, Female, Follow-Up Studies, Greece, Humans, Incidence, Liver Transplantation, Male, Middle Aged, Renal Replacement Therapy, Retrospective Studies, Risk Factors, Survival Rate, Time Factors
Abstract

BACKGROUND: Renal dysfunction is commonly found in patients with end-stage liver disease, as well as after liver transplantation, and it often needs renal replacement therapy (RRT) with the application of continuous or intermittent methods. The aim of this study was the recording of the patients who underwent continuous venovenous hemodiafiltration (CVVHDF) in the early postoperative period, as well as the recording of mortality and risk factors.METHODS: We retrospectively examined 71 patients who underwent orthotopic liver transplantation during a 2-year period (2011-2012). We recorded the incidence of acute kidney injury (AKI), according to the Acute Kidney Injury Network criteria, and we distinguished 2 groups of patients. Group A included those who needed RRT during the 1st 7 days after transplantation, and group B included the patients who did not require RRT. The RRT method of choice was CVVHDF.RESULTS: In group A, the population of patients who presented AKI reached 52.1%, and 22.5% of the them underwent RRT. The mean Model for End-Stage Liver Disease and Acute Physiology and Chronic Health Evaluation scores were higher in group A, who also presented greater hemodynamic instability and more frequent infections and required more transfusions. The transfusion of >10 units of red blood cells was recognized as a risk factor for RRT (P = .024; odds ratio, 1.15; 95% confidence interval, 1.8-7.53).CONCLUSIONS: Patients who required RRT immediately after surgery had a significantly higher rate of mortality and it seemed that the number of transfusions played an important role in this.

DOI10.1016/j.transproceed.2014.09.162
Alternate JournalTransplant. Proc.
PubMed ID25420866

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