Cochlear implantation in patients with MELAS syndrome.
Τίτλος | Cochlear implantation in patients with MELAS syndrome. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Karkos, P. D., Anari S., & Johnson I. J. |
Journal | Eur Arch Otorhinolaryngol |
Volume | 262 |
Issue | 4 |
Pagination | 322-4 |
Date Published | 2005 Apr |
ISSN | 0937-4477 |
Λέξεις κλειδιά | Adult, Cochlear Implantation, Female, Hearing Loss, Sensorineural, Humans, MELAS Syndrome, Middle Aged, Speech Reception Threshold Test, Treatment Outcome |
Abstract | MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) is a rare congenital disorder of mitochondrial DNA (mt-DNA). Patients with this syndrome may present to the otolaryngologist with sensorineural hearing loss (SNHL) that is genetic in origin. Mitochondrial cytopathies can present with a variety of symptoms, but they occasionally present with SNHL as their first manifestation. Two cases of MELAS patients who responded well to cochlear implantation are presented. A review of the literature is also carried out focusing mainly on diagnosis, anesthetic considerations and management of these patients. |
DOI | 10.1007/s00405-004-0817-x |
Alternate Journal | Eur Arch Otorhinolaryngol |
PubMed ID | 15841411 |