The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: A cross-sectional study.
Τίτλος | The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: A cross-sectional study. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Karras, S. N., Anagnostis P., Antonopoulou V., Tsekmekidou X., Koufakis T., Goulis D. G., Zebekakis P., & Kotsa K. |
Journal | Diab Vasc Dis Res |
Volume | 15 |
Issue | 2 |
Pagination | 150-153 |
Date Published | 2018 Mar |
ISSN | 1752-8984 |
Λέξεις κλειδιά | Aged, Aged, 80 and over, Blood Glucose, Body Mass Index, Cross-Sectional Studies, Fasting, Female, Homeostasis, Humans, Insulin Resistance, Male, Middle Aged, Parathyroid Hormone, Prediabetic State, Vitamin D, Vitamin D Deficiency |
Abstract | BACKGROUND: The combined effect of vitamin D and parathyroid hormone on glucose homeostasis has not been adequately investigated. The aim of this study was to examine the role of parathyroid hormone/vitamin D axis on glucose homeostasis in elderly persons with prediabetes.METHODS: Patients with prediabetes ( n = 144) and healthy age-matched controls ( n = 81) were included in this cross-sectional study. Study parameters included anthropometric characteristics, morning fasting glucose (fasting plasma glucose), insulin (fasting plasma insulin), parathyroid hormone, 25-hydroxyvitamin D, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function. Both groups were stratified into subgroups according to vitamin D status and tertiles of parathyroid hormone.RESULTS: Both groups were comparable in terms of body mass index, 25-hydroxyvitamin D and parathyroid hormone status. In the prediabetes group, fasting plasma glucose differed significantly across parathyroid hormone tertiles, increasing from the first to the third tertile ( p = 0.011). There were higher fasting plasma glucose values in participants with vitamin D deficiency/parathyroid hormone third tertile compared to all other groups ( p = 0.031, 0.027 and 0.039, respectively).CONCLUSION: Parathyroid hormone status is associated with impaired glucose homeostasis; hypovitaminosis D combined with high parathyroid hormone concentrations are associated with glycaemic dysregulation in elderly patients with prediabetes. |
DOI | 10.1177/1479164117738443 |
Alternate Journal | Diab Vasc Dis Res |
PubMed ID | 29113459 |