Comparative immunohistochemical analysis of aurora-A and aurora-B expression in human glioblastomas. Associations with proliferative activity and clinicopathological features.
Τίτλος | Comparative immunohistochemical analysis of aurora-A and aurora-B expression in human glioblastomas. Associations with proliferative activity and clinicopathological features. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Samaras, V., Stamatelli A., Samaras E., Arnaoutoglou C., Arnaoutoglou M., Stergiou I., Konstantopoulou P., Varsos V., Karameris A., & Barbatis C. |
Journal | Pathol Res Pract |
Volume | 205 |
Issue | 11 |
Pagination | 765-73 |
Date Published | 2009 |
ISSN | 1618-0631 |
Λέξεις κλειδιά | Adult, Aged, Aged, 80 and over, Analysis of Variance, Brain Neoplasms, Cell Proliferation, Cerebral Cortex, Combined Modality Therapy, Female, Glioblastoma, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Ki-67 Antigen, Male, Middle Aged, Protein-Serine-Threonine Kinases, Statistics, Nonparametric, Treatment Outcome |
Abstract | In the present study, we carried out a comparative immunohistochemical analysis of aurora-A and aurora-B expression in 40 patients with primary glioblastomas, and attempted to identify any associations with Ki-67 index and the patients' clinical features. The impact of various treatment modalities and proliferative activity on patient outcome was also assessed. Immunohistochemistry was carried out using formalin-fixed and paraffin-embedded tissue sections. Aurora-A expression was higher in tumors with high Ki-67 expression (p=0.01) and was positively, though marginally, related to aurora-B expression (p=0.085). Aurora-B expression was not linked to Ki-67 expression (p=0.182). Lower aurora-A immunohistochemical expression, chemotherapy administration, and tumor localization in one lobe of the brain implied a greater probability of patient survival in univariate analysis (p=0.044, p=0.008, p=0.041, respectively). Ki-67 and aurora-B immunoreactivities were not associated with patient survival (p=0.918 and p=0.539, respectively). To our knowledge, for the first time, the association between aurora-A and aurora-B expression, the correlation of aurora-A with Ki-67 index, and the prognostic impact of aurora-A expression were assessed in glioblastomas. Although we addressed a prognostic connotation of aurora-A, we presume that aurora-A and aurora-B play a complicated role within glioblastomas. Further examinations of larger series are required, so that definite conclusions can be drawn. |
DOI | 10.1016/j.prp.2009.06.011 |
Alternate Journal | Pathol. Res. Pract. |
PubMed ID | 19616898 |