Comparative study of dual energy X-ray absorptiometry and quantitative ultrasonography with the use of biochemical markers of bone turnover in boys with haemophilia.
Τίτλος | Comparative study of dual energy X-ray absorptiometry and quantitative ultrasonography with the use of biochemical markers of bone turnover in boys with haemophilia. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Christoforidis, A., Economou M., Papadopoulou E., Kazantzidou E., Farmaki E., Tzimouli V., Tsatra I., Gompakis N., & Athanassiou-Metaxa M. |
Journal | Haemophilia |
Volume | 17 |
Issue | 1 |
Pagination | e217-22 |
Date Published | 2011 Jan |
ISSN | 1365-2516 |
Λέξεις κλειδιά | Absorptiometry, Photon, Adolescent, Biological Markers, Bone Density, Bone Diseases, Metabolic, Child, Child, Preschool, Hemophilia A, Humans, Lumbar Vertebrae, Male, NF-kappa B, Osteocalcin, Osteoporosis, Osteoprotegerin, Radius, RANK Ligand, Reference Values, Risk Factors, Tibia |
Abstract | Our aim was to evaluate bone status in boys with haemophilia using dual energy X-ray absorptiometry (DXA) and quantitative ultraSonography (QUS), and in addition, to compare these two methods with the use of biochemical markers of bone turnover. Twenty-six boys with a mean decimal age of 12.08 ± 4.44 years were included in the study which included a DXA scan at lumbar spine and radial, as well as tibial QUS. Serum levels of soluble receptor activator of nuclear factor κB ligand (sRANK-L), osteoprotegerin (OPG) and osteocalcin (OC) were measured and joint evaluation was performed using the Hemophilia Joint Health Score (HJHS). With regard to the study results, only 2 of 26 patients (7.7%) had bone mineral density (BMD) Z-scores < -2, and 4 patients (15.4%) had BMD Z-scores between -1 and -2. Only one patient had radial and other two had tibial QUS Z-scores < -2. No agreement was recorded between QUS and DXA in identifying patients at risk for osteoporosis (k = 0.275, P = 0.063). Haemophiliacs had significantly higher serum levels of sRANK-L (21.04 ± 4.78 vs. 18.58 ± 2.28 ng mL(-1), P = 0.038) and of OC (5.35 ± 2.29 vs. 3.09 ± 0.61 ng mL(-1), P = 0.002) and significantly decreased levels of OPG (15.78 ± 2.53 vs. 23.79 ± 4.39 pg mL(-1), P < 0.001) compared with controls. QUS Z-scores at tibia significantly correlated with HJH Scores (r = -0.450, P = 0.040), whereas lumbar BMD Z-scores significantly correlated with body mass index Z-scores (r = 0.500, P = 0.009). More studies are warranted to identify the most accurate densitometric method for assessing bone status in haemophiliacs. |
DOI | 10.1111/j.1365-2516.2010.02385.x |
Alternate Journal | Haemophilia |
PubMed ID | 20825502 |