Consequences of anorectal cancer atlas implementation in the cooperative group setting: radiobiologic analysis of a prospective randomized in silico target delineation study.
Τίτλος | Consequences of anorectal cancer atlas implementation in the cooperative group setting: radiobiologic analysis of a prospective randomized in silico target delineation study. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Mavroidis, P., Giantsoudis D., Awan M. J., Nijkamp J., Rasch C. R. N., Duppen J. C., Thomas C. R., Okunieff P., Jones W. E., Kachnic L. A., Papanikolaou N., & Fuller C. D. |
Corporate Authors | Southwest Oncology Group Radiation Oncology Committee |
Journal | Radiother Oncol |
Volume | 112 |
Issue | 3 |
Pagination | 418-24 |
Date Published | 2014 Sep |
ISSN | 1879-0887 |
Λέξεις κλειδιά | Computer Simulation, Consensus, Cooperative Behavior, Humans, Male, Observer Variation, Practice Guidelines as Topic, Prospective Studies, Radiobiology, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Intensity-Modulated, Rectal Neoplasms, Tumor Burden |
Abstract | PURPOSE: The aim of this study is to ascertain the subsequent radiobiological impact of using a consensus guideline target volume delineation atlas.MATERIALS AND METHODS: Using a representative case and target volume delineation instructions derived from a proposed IMRT rectal cancer clinical trial, gross tumor volume (GTV) and clinical/planning target volumes (CTV/PTV) were contoured by 13 physician observers (Phase 1). The observers were then randomly assigned to follow (atlas) or not-follow (control) a consensus guideline/atlas for anorectal cancers, and instructed to re-contour the same case (Phase 2).RESULTS: The atlas group was found to have increased tumor control probability (TCP) after the atlas intervention for both the CTV (p<0.0001) and PTV1 (p=0.0011) with decreasing normal tissue complication probability (NTCP) for small intestine, while the control group did not. Additionally, the atlas group had reduced variance in TCP for all target volumes and reduced variance in NTCP for the bowel. In Phase 2, the atlas group had increased TCP relative to the control for CTV (p=0.03).CONCLUSIONS: Visual atlas and consensus treatment guideline usage in the development of rectal cancer IMRT treatment plans reduced the inter-observer radiobiological variation, with clinically relevant TCP alteration for CTV and PTV volumes. |
DOI | 10.1016/j.radonc.2014.05.011 |
Alternate Journal | Radiother Oncol |
PubMed ID | 24996454 |
PubMed Central ID | PMC4258107 |
Grant List | L30 CA136381 / CA / NCI NIH HHS / United States L30 CA136381-01 / CA / NCI NIH HHS / United States U10 CA032102 / CA / NCI NIH HHS / United States U10 CA180888 / CA / NCI NIH HHS / United States |