Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5.
Τίτλος | Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Petsanis, K., Chatzisotiriou A., Kapoukranidou D., Simeonidou C., Kouvelas D., & Albani M. |
Journal | BMC Physiol |
Volume | 12 |
Pagination | 5 |
Date Published | 2012 May 02 |
ISSN | 1472-6793 |
Λέξεις κλειδιά | 2-Amino-5-phosphonovalerate, Animals, Animals, Newborn, Axotomy, Behavior, Animal, Excitatory Amino Acid Antagonists, Female, Male, Motor Neurons, Movement, Muscle Contraction, Muscle Denervation, Muscle, Skeletal, N-Methylaspartate, Nerve Crush, Rats, Wistar |
Abstract | BACKGROUND: It is well known that axotomy in the neonatal period causes massive loss of motoneurons, which is reflected in the reduction of the number of motor units and the alteration in muscle properties. This type of neuronal death is attributed to the excessive activation of the ionotropic glutamate receptors (glutamate excitotoxicity). In the present study we investigated the effect of the NMDA antagonist DAP5 [D-2-amino-5-phosphonopentanoic acid] in systemic administration, on muscle properties and on behavioural aspects following peripheral nerve injury. |
DOI | 10.1186/1472-6793-12-5 |
Alternate Journal | BMC Physiol |
PubMed ID | 22551202 |
PubMed Central ID | PMC3395568 |