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The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients.

ΤίτλοςThe controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients.
Publication TypeJournal Article
Year of Publication2015
AuthorsTsachouridou, O., Skoura L., Zebekakis P., Margariti A., Georgiou A., Daniilidis M., Malisiovas N., & Metallidis S.
JournalInt J Infect Dis
Volume38
Pagination24-31
Date Published2015 Sep
ISSN1878-3511
Abstract

BACKGROUND: Chronic HIV infection leads to severe perturbations of the B cell populations and hypo-responsiveness to vaccines. The associations between circulating B cell subpopulations and the antibody response to pneumococcal polysaccharide vaccine in antiretroviral-naïve and treated patients were studied.METHODS: Sixty-six HIV-infected adults were grouped according to antiretroviral therapy (ART) and CD4+ cell count; 31 were ART-naïve and 35 were ART-treated, and they were matched for age, CD4 cell count, and duration of HIV infection. All subjects were immunized with the 23-valent polysaccharide vaccine against Streptococcus pneumoniae. Pre- and post-vaccination B cell subpopulations were assessed by flow cytometry. Serum IgG concentrations for vaccine serotypes were quantified by ELISA at baseline and at 4 and 48 weeks post-vaccination.RESULTS: Patients under highly active antiretroviral therapy (HAART) had significantly higher antibody levels against pneumococcal vaccine antigens, while an adequate number of patients responded to vaccination. Memory B cells were diminished over time, although treated patients maintained higher levels of all subsets studied, with the exception of activated memory and isotype-switched memory B cells.CONCLUSIONS: Low concentrations of total B cells and exhausted memory B cells was the strongest independent predictor of poor pneumococcal vaccine responsiveness, emphasizing that B cell subset disturbances are associated with a poor vaccine response among HIV-infected patients.

DOI10.1016/j.ijid.2015.07.008
Alternate JournalInt. J. Infect. Dis.
PubMed ID26192868

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Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

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