The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients.
Τίτλος | The controversial impact of B cells subsets on immune response to pneumococcal vaccine in HIV-1 patients. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Tsachouridou, O., Skoura L., Zebekakis P., Margariti A., Georgiou A., Daniilidis M., Malisiovas N., & Metallidis S. |
Journal | Int J Infect Dis |
Volume | 38 |
Pagination | 24-31 |
Date Published | 2015 Sep |
ISSN | 1878-3511 |
Abstract | BACKGROUND: Chronic HIV infection leads to severe perturbations of the B cell populations and hypo-responsiveness to vaccines. The associations between circulating B cell subpopulations and the antibody response to pneumococcal polysaccharide vaccine in antiretroviral-naïve and treated patients were studied.METHODS: Sixty-six HIV-infected adults were grouped according to antiretroviral therapy (ART) and CD4+ cell count; 31 were ART-naïve and 35 were ART-treated, and they were matched for age, CD4 cell count, and duration of HIV infection. All subjects were immunized with the 23-valent polysaccharide vaccine against Streptococcus pneumoniae. Pre- and post-vaccination B cell subpopulations were assessed by flow cytometry. Serum IgG concentrations for vaccine serotypes were quantified by ELISA at baseline and at 4 and 48 weeks post-vaccination.RESULTS: Patients under highly active antiretroviral therapy (HAART) had significantly higher antibody levels against pneumococcal vaccine antigens, while an adequate number of patients responded to vaccination. Memory B cells were diminished over time, although treated patients maintained higher levels of all subsets studied, with the exception of activated memory and isotype-switched memory B cells.CONCLUSIONS: Low concentrations of total B cells and exhausted memory B cells was the strongest independent predictor of poor pneumococcal vaccine responsiveness, emphasizing that B cell subset disturbances are associated with a poor vaccine response among HIV-infected patients. |
DOI | 10.1016/j.ijid.2015.07.008 |
Alternate Journal | Int. J. Infect. Dis. |
PubMed ID | 26192868 |