Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model.
Τίτλος | Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Idan-Feldman, A., Schirer Y., Polyzoidou E., Touloumi O., Lagoudaki R., Grigoriadis N. C., & Gozes I. |
Journal | Neurobiol Dis |
Volume | 44 |
Issue | 3 |
Pagination | 327-39 |
Date Published | 2011 Dec |
ISSN | 1095-953X |
Λέξεις κλειδιά | Animals, Caspase 3, Central Nervous System Diseases, Cognition Disorders, Diabetes Mellitus, Experimental, Disease Models, Animal, Lectins, Magnetic Resonance Imaging, Male, Maze Learning, Mental Disorders, Neuroprotective Agents, Oligopeptides, Phosphopyruvate Hydratase, Rats, Rats, Sprague-Dawley, Reaction Time, Social Behavior, Space Perception, Synaptophysin, Time Factors |
Abstract | AIMS: Central nervous system complications including cognitive impairment are an early manifestation of diabetes mellitus, also evident in animal models. NAP (generic name, davunetide), a neuroprotective peptide was tested here for its ability to prevent diabetes-related brain pathologies in the streptozotocin injected diabetes rat model. |
DOI | 10.1016/j.nbd.2011.06.020 |
Alternate Journal | Neurobiol. Dis. |
PubMed ID | 21827858 |