Diagnostic Value of F-FDG-PET/CT in Patients with FUO.
Τίτλος | Diagnostic Value of F-FDG-PET/CT in Patients with FUO. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Georga, S., Exadaktylou P., Petrou I., Katsampoukas D., Mpalaris V., Moralidis E-I., Arvaniti K., Papastergiou C., & Arsos G. |
Journal | J Clin Med |
Volume | 9 |
Issue | 7 |
Date Published | 2020 Jul 04 |
ISSN | 2077-0383 |
Abstract | Conventional diagnostic imaging is often ineffective in revealing the underlying cause in a considerable proportion of patients with fever of unknown origin (FUO). The aim of this study was to assess the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT) in patients with FUO. We retrospectively reviewed F-FDG-PET/CT scans performed on 50 consecutive adult patients referred to our department for further investigation of classic FUO. Final diagnosis was based on histopathological and microbiological findings, clinical criteria, or clinical follow-up. Final diagnosis was established in 39/50 (78%) of the patients. The cause of FUO was infection in 20/50 (40%), noninfectious inflammatory diseases in 11/50 (22%), and malignancy in 8/50 (16%) patients. Fever remained unexplained in 11/50 (22%) patients. F-FDG-PET/CT scan substantially contributed to the diagnosis in 70% of the patients, either by identifying the underlying cause of FUO or by directing to the most appropriate site for biopsy. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of F-FDG-PET/CT for active disease detection in patients with FUO were 94.7%, 50.0%, 84.0%, 85.7%, and 75.0%, respectively. In conclusion, whole-body F-FDG-PET/CT is a highly sensitive method for detection of the underlining cause of FUO or for correctly targeting suspicious lesions for further evaluation. |
DOI | 10.3390/jcm9072112 |
Alternate Journal | J Clin Med |
PubMed ID | 32635566 |
PubMed Central ID | PMC7408628 |