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DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.

ΤίτλοςDIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions.
Publication TypeJournal Article
Year of Publication2015
AuthorsVlachos, I. S., Paraskevopoulou M. D., Karagkouni D., Georgakilas G., Vergoulis T., Kanellos I., Anastasopoulos I-L., Maniou S., Karathanou K., Kalfakakou D., Fevgas A., Dalamagas T., & Hatzigeorgiou A. G.
JournalNucleic Acids Res
Volume43
IssueDatabase issue
PaginationD153-9
Date Published2015 Jan
ISSN1362-4962
Λέξεις κλειδιάAbstracting and Indexing as Topic, Binding Sites, Data Mining, Databases, Nucleic Acid, Internet, MicroRNAs, RNA, Messenger, User-Computer Interface
Abstract

microRNAs (miRNAs) are short non-coding RNA species, which act as potent gene expression regulators. Accurate identification of miRNA targets is crucial to understanding their function. Currently, hundreds of thousands of miRNA:gene interactions have been experimentally identified. However, this wealth of information is fragmented and hidden in thousands of manuscripts and raw next-generation sequencing data sets. DIANA-TarBase was initially released in 2006 and it was the first database aiming to catalog published experimentally validated miRNA:gene interactions. DIANA-TarBase v7.0 (http://www.microrna.gr/tarbase) aims to provide for the first time hundreds of thousands of high-quality manually curated experimentally validated miRNA:gene interactions, enhanced with detailed meta-data. DIANA-TarBase v7.0 enables users to easily identify positive or negative experimental results, the utilized experimental methodology, experimental conditions including cell/tissue type and treatment. The new interface provides also advanced information ranging from the binding site location, as identified experimentally as well as in silico, to the primer sequences used for cloning experiments. More than half a million miRNA:gene interactions have been curated from published experiments on 356 different cell types from 24 species, corresponding to 9- to 250-fold more entries than any other relevant database. DIANA-TarBase v7.0 is freely available.

DOI10.1093/nar/gku1215
Alternate JournalNucleic Acids Res.
PubMed ID25416803
PubMed Central IDPMC4383989

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