Digital dermoscopic changes during follow-up of de-novo and nevus-associated melanoma: a cohort study.
Τίτλος | Digital dermoscopic changes during follow-up of de-novo and nevus-associated melanoma: a cohort study. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Pampena, R., Manfreda V., Kyrgidis A., Lai M., Borsari S., Benati E., Lombardi M., Bianchi L., Zalaudek I., Moscarella E., Lallas A., Argenziano G., Pellacani G., & Longo C. |
Journal | Int J Dermatol |
Volume | 59 |
Issue | 7 |
Pagination | 813-821 |
Date Published | 2020 Jul |
ISSN | 1365-4632 |
Abstract | BACKGROUND: Nevus-associated melanoma (NAM) has been regarded as a distinct biological entity from de-novo melanoma (DNM); however, static dermoscopy often fails in differentiating these entities. Digital dermoscopic monitoring allows to identify dynamic changes occurring during follow-up; this may improve diagnostic accuracy and potentially our knowledge on NAM biology. We aimed to define main independent factors associated with NAM diagnosis and those influencing follow-up time in a population of melanomas excised at follow-up.METHODS: A cohort of melanomas excised at follow-up was retrospectively and consecutively selected. NAMs and DNMs were compared according to baseline features and main dermoscopic changes occurring during follow-up. Univariate and multivariable logistic and Cox's regression analysis were performed to respectively define factors associated with NAM diagnosis and those influencing the risk for excision.RESULTS: Eighty-six melanomas were enrolled, of which 21 (24.4%) were nevus-associated. During follow-up NAMs mainly underwent atypical network modifications (47.6%), followed by inverse network (28.6%) and dermoscopic island (23.8%) worsening or appearance. DNMs were also mainly characterized by atypical network modifications (47.7%), however, a significant proportion of cases underwent irregular pigmentation/dots/globules or regression changes (29.2%), which were rarely seen among NAMs. Furthermore, both multivariable logistic and Cox's regression analysis demonstrated a significant association between NAM and a longer follow-up.CONCLUSIONS: We demonstrated that among melanomas excised at follow-up, different patterns of dermoscopic changes may be found between NAMs and DNMs. This finding, together with the association of NAM with a longer follow-up time, supports the hypothesis of different biological behavior of these two entities. |
DOI | 10.1111/ijd.14918 |
Alternate Journal | Int J Dermatol |
PubMed ID | 32406113 |