DNA methylation analysis within the IL2RA gene promoter in youth with autoimmune thyroid disease.
Τίτλος | DNA methylation analysis within the IL2RA gene promoter in youth with autoimmune thyroid disease. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Kyrgios, I., Fragou A., Kotanidou E. P., Mouzaki K., Efraimidou S., Tzimagiorgis G., & Galli-Tsinopoulou A. |
Journal | Eur J Clin Invest |
Volume | 50 |
Issue | 3 |
Pagination | e13199 |
Date Published | 2020 Mar |
ISSN | 1365-2362 |
Λέξεις κλειδιά | Child, DNA Methylation, Female, Humans, Interleukin-2 Receptor alpha Subunit, Male, Promoter Regions, Genetic, Thyroiditis, Autoimmune |
Abstract | BACKGROUND: Alpha-subunit of the interleukin-2 receptor (IL2RA) is involved in the regulation of T-cell function and has been related to autoimmune thyroid disease (AITD). Although the exact mechanisms are not fully understood, promoter methylation might account for differences in gene expression. The aim of this study was to investigate whether there are differences in the percentage of DNA methylation within the IL2RA gene promoter in young patients with AITD. |
DOI | 10.1111/eci.13199 |
Alternate Journal | Eur J Clin Invest |
PubMed ID | 31943147 |
Grant List | 89650 / / Research Committee of the Aristotle University of Thessaloniki / |