Drug-resistant tuberculosis in two children in Greece: report of the first extensively drug-resistant case.
| Τίτλος | Drug-resistant tuberculosis in two children in Greece: report of the first extensively drug-resistant case. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Katragkou, A., Antachopoulos C., Hatziagorou E., Sdougka M., Roilides E., & Tsanakas J. |
| Journal | Eur J Pediatr |
| Volume | 172 |
| Issue | 4 |
| Pagination | 563-7 |
| Date Published | 2013 Apr |
| ISSN | 1432-1076 |
| Λέξεις κλειδιά | Antitubercular Agents, Child, Preschool, Extensively Drug-Resistant Tuberculosis, Fatal Outcome, Female, Greece, Humans, Infant, Male, Tuberculosis, Central Nervous System, Tuberculosis, Pulmonary |
| Abstract | Extensively drug-resistant (XDR) tuberculosis (TB) represents a serious and growing problem in both endemic and non-endemic countries. We describe a 2.5-year-old girl with XDR-pulmonary TB and an 18-month-old boy with pre-XDR-central nervous system TB. Patients received individualized treatment with second-line anti-TB agents based on genotypic and phenotypic drug susceptibility testing results. Both children achieved culture conversion 3 months and 1 month after treatment initiation, respectively. The child with XDR-pulmonary TB showed evidence of cure while treatment adverse events were managed without treatment interruption. The child with pre-XDR-central nervous system TB after 6-month hospitalization with multiple infectious complications had a dismal end due to hepatic insufficiency possibly related to anti-TB treatment. This is the first report of children with pre-XDR and XDR TB in Greece, emphasizing the public health dimensions and management complexity of XDR TB. |
| DOI | 10.1007/s00431-012-1811-8 |
| Alternate Journal | Eur. J. Pediatr. |
| PubMed ID | 22907397 |
