Δημοσίευση

Dynamics of Epileptiform Discharges Induced by Transcranial Magnetic Stimulation in Genetic Generalized Epilepsy.

ΤίτλοςDynamics of Epileptiform Discharges Induced by Transcranial Magnetic Stimulation in Genetic Generalized Epilepsy.
Publication TypeJournal Article
Year of Publication2017
AuthorsKugiumtzis, D., Koutlis C., Tsimpiris A., & Kimiskidis V. K.
JournalInt J Neural Syst
Volume27
Issue7
Pagination1750037
Date Published2017 Nov
ISSN1793-6462
Λέξεις κλειδιάBrain, Brain Waves, Child, Electroencephalography, Epilepsy, Generalized, Female, Humans, Male, Models, Neurological, Multivariate Analysis, Neural Pathways, Nonlinear Dynamics, Numerical Analysis, Computer-Assisted, Transcranial Magnetic Stimulation
Abstract

OBJECTIVE: In patients with Genetic Generalized Epilepsy (GGE), transcranial magnetic stimulation (TMS) can induce epileptiform discharges (EDs) of varying duration. We hypothesized that (a) the ED duration is determined by the dynamic states of critical network nodes (brain areas) at the early post-TMS period, and (b) brain connectivity changes before, during and after the ED, as well as within the ED.METHODS: EEG recordings from two GGE patients were analyzed. For hypothesis (a), the characteristics of the brain dynamics at the early ED stage are measured with univariate and multivariate EEG measures and the dependence of the ED duration on these measures is evaluated. For hypothesis (b), effective connectivity measures are combined with network indices so as to quantify the brain network characteristics and identify changes in brain connectivity.RESULTS: A number of measures combined with specific channels computed on the first EEG segment post-TMS correlate with the ED duration. In addition, brain connectivity is altered from pre-ED to ED and post-ED and statistically significant changes were also detected across stages within the ED.CONCLUSION: ED duration is not purely stochastic, but depends on the dynamics of the post-TMS brain state. The brain network dynamics is significantly altered in the course of EDs.

DOI10.1142/S012906571750037X
Alternate JournalInt J Neural Syst
PubMed ID28774230

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