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The effect of myelotomy following low thoracic spinal cord compression injury in rats.

ΤίτλοςThe effect of myelotomy following low thoracic spinal cord compression injury in rats.
Publication TypeJournal Article
Year of Publication2018
AuthorsMeyer, C., Bendella H., Rink S., Gensch R., Seitz R., Stein G., Manthou M., Papamitsou T., Nakamura M., Bouillon B., Galea M., Batchelor P., Dunlop S., & Angelov D.
JournalExp Neurol
Volume306
Pagination10-21
Date Published2018 Aug
ISSN1090-2430
Abstract

Myelotomy is a surgical procedure allowing removal of extravasated blood and necrotic tissue that is thought to attenuate secondary injury as well as promote recovery in experimental spinal cord injury (SCI) models and humans. Here we examined in rat whether myelotomy at 48 h after low-thoracic compressive SCI provided any benefit over a 12 week period. Compared to animals receiving SCI alone, myelotomy worsened BBB scores (p < 0.05) and also did not improve plantar stepping, ladder climbing, urinary bladder voiding or sensory function (thermal latency) during the 12-week period. Quantitative analyses of tissue sections at 12 weeks showed that myelotomy also did not reduce lesion volume nor alter immunohistochemical markers of axons in spared white matter bridges, microglia, astrocytes or serotinergic fibres. However, myelotomy reduced synaptophysin expression, a marker of synaptic plasticity. We conclude that further studies are required to evaluate myelotomy after SCI. (142 words).

DOI10.1016/j.expneurol.2018.04.011
Alternate JournalExp. Neurol.
PubMed ID29679548

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Τμήμα Ιατρικής, Πανεπιστημιούπολη ΑΠΘ, T.K. 54124, Θεσσαλονίκη
 

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